Hepatitis C and
Its Relation to B-Cell Lymphoma
Hepatitis C virus (HCV) infection is a global health
concern, with millions of people chronically infected. The course of this
chronic disease may lead to lymphoproliferative disorders ranging from benign
mixed cryoglobulinemia to malignant non-Hodgkin lymphoma (NHL). In this
article, we reviewed the current knowledge of the different pathologic
mechanisms involved in the occurrence of HCV-related lymphoproliferative
diseases. Hepatitis C virus directly or indirectly causes different steps of
progressive alterations. A chronic antigenic stimulation will select a B-cell
clone that will gain immortality via alterations in coding DNA in
proto-oncogenes and tumoursuppressor regions. The main challenge in the
treatment of HCV-induced NHL is to obtain a sustained virologic response before
HCV induced irreversible damages leading to everlasting cell survival. The new
interferon-free therapies introduce a new era of management of HCV-NHL, with
recent published data to be promising. Nevertheless, further studies are
required to assess the safety of those drugs, particularly in association with
chemotherapy.
Sumber : http://insights.sagepub.com/
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