Immunity
Against Fungal Infections
Fungal diseases are major causes of morbidity and
mortality among the immunocompromised, including HIV-infected individuals and
patients with cancer. Individuals without a weakened immune system can also
suffer from these infections. Not surprisingly, fungi are a major target for
the immune system, rendered visible to it by expression of pathogen-associated
molecular patterns/signatures. We now appreciate the roles of both innate and
adaptive immunity in eliminating fungal infections, and how a disproportionate
or inadequate immune response can diminish the host’s capacity to eliminate
fungi. This review focuses on our current understanding of the roles of innate
and adaptive immunity in clearing common and emergent fungal pathogens. A
clearer understanding of how the host’s immune response tackles fungal
infection may provide useful clues as to how we might develop new agents to
treat those diseases in the future.
Sumber : http://insights.sagepub.com/
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