Effect of
Supplementation With Chitosan on Weight, Cardiometabolic, and Other Risk
Indices in Wistar Rats Fed Normal and High-Fat/High-Cholesterol Diets Ad
Libitum
The
aim was to investigate effect of chitosan on markers of obesity and
cardiometabolic risk in rats fed normal chow (NC) or highfat/high-cholesterol
diet (HF/HCD). Forty male rats were fed NC or HF/HCD for 3months, then divided
into 4 groups: group A fed NC, group B: NC+chitosan, group C: HF/HCD, and group
D: HF/HCD+chitosan. Food intake and weight were recorded, and serum glucose,
lipid profile, insulin, leptin, gamma glutamyl transferase (GGT), and tumor
necrosis factor α were measured at beginning and after 12weeks. Atherogenic
index (AI), low-density lipoprotein cholesterol:high-density lipoprotein
cholesterol (LDL-C:HDL-C), and homeostatic model assessment of insulin
resistance (HOMA-IR) were calculated. At the end of study, food intake was
significantly increased in group B; mean values of triglycerides, total
cholesterol, LDL-C, LDL-C:HDL-C, and AI were decreased in group B and group D;
mean leptin was increased in group A and decreased in group B; and mean values
of insulin, HOMA-IR, and GGT were increased in group C. The results from this
study suggest that chitosan improved lipid profile, insulin sensitivity, and
oxidative stress caused by HF/HCD.
Sumber : http://insights.sagepub.com/
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